Comprehensive COLARIS AP®
GENETIC VARIANT OF UNCERTAIN SIGNIFICANCE
 The term genetic variant of uncertain clinical significance means that the tests found a genetic change in APC or MYH but its relationship to hereditary cancer and polyposis, if any, is not yet known. At the present time, your patient's medical management should be based on the strength of his/her personal and family history of cancer, similar to the approach for a no mutation detected result. For more information on this topic, please click here for details on this concept and case examples to illustrate important points.
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COLARIS AP® Genetic Variant of Uncertain Significance
Research is ongoing to determine the meaning of genetic variants of uncertain significance. Past studies show that many genetic variants turn out to be harmless or unrelated to increased cancer risk. For this reason, you should NOT assume that variant result is actually a disease-causing mutation. However, a small number of uncertain variants have also been shown to be deleterious or associated with increased cancer risk. Thus, you should also NOT assume that the variant result is benign.
Each time a genetic variant of uncertain significance is reported, a report with additional information is included. This report is referred to as the MGA form.
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