Single Site COLARIS AP®
POSITIVE FOR A DELETERIOUS MUTATION IN THE APC GENE
 This test result means that
the known familial deleterious mutation was found in the APC gene, indicating a diagnosis of familial adenomatous polyposis (FAP) or attenuated FAP (AFAP). These adenomatous polyposis syndromes are associated with an increased risk for colorectal adenomas and various other associated cancers. If your patient has already been diagnosed with cancer and/or colorectal adenomas, he/she is at increased risk for second primary cancers and colorectal adenomas. Click here to a view a list of published estimates of cancer risks for APC mutation carriers.
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COLARIS AP® Positive for a Deleterious Mutation or Suspected Deleterious
A
positive for a deleterious mutation in the APC gene result allows you to personalize your patient's medical management, as the diagnosis of FAP or AFAP is genetically confirmed. It also enables other family members to determine whether they also inherited the mutation and its associated cancer susceptibility. The approach to managing this result is the same as the approach to a positive APC result detected on Comprehensive COLARIS AP®. Click here for information on a positive for a deleterious mutation in the APC gene result.
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