Single Site COLARIS AP®
POSITIVE FOR TWO COPIES OF AN MYH MUTATION
 This test result means that the test detected
the known familial deleterious mutations in both of the MYH genes, indicating a diagnosis of MYH-associated polyposis (MAP). This syndrome is associated with an increased risk of colorectal adenomas and cancer. Cancer risks for MAP are currently unknown, although the association with multiple adenomas is thought to increase the risk of colon cancer significantly.
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COLARIS AP® Positive for Two Copies of an MYH Mutation
This result allows you to personalize your patient's medical management, as the diagnosis of MAP is genetically confirmed. It also enables other family members to determine whether they also inherited both of the mutations and the associated cancer susceptibility.
The approach to managing this result is the same as the approach to a biallelic MYH result detected on Comprehensive COLARIS AP®. Click here for information on a positive for two copies of an MYH mutation result.
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